Before I get into this guide, I want to preface that this is what I personally believe to be the best route and build for Chalice DoK. This isn't related to RoR team Views and such either, Just me as a player

Mastery Build -

This is what I run on my DoK. Tactics are Discipline, Bound by Blood, Khaine's Bounty, and efficient patching. Some honorable mentions for tactics you can run are Restored Motivation, Potent Covenants, Khaine's Vivification and Resto burst. Depends how you want to play.
Mastery you'll pick up The 2 tactics I already mentioned that I run (Khaine's Bounty and Eff. Patching.) then Khaine's Vigor and Khaine's Refreshment. Then you'll move into Path of Sacrifice and pick up Devour Essence, very useful ability to throw on your MDPS or Tanks.
Renown -


This is how I run my renown, 2 Init, 4 Toughness, 3 Wounds, then Full Heal Crit. the 1 willpower was just to throw my last point somewhere "useful". With Toughness, you are going to feel a good difference in survivability at sub 200 toughness compared to sitting roughly at 350. Initiative is just so I don't have to put any points into Futile Strikes. When you are leveling, you will need to put points into futile strikes so you can be at 0% chance to crit, or near. but once you get into BiS you can get to a point where you don't need any points into it.
Gearing -
Decimator (Tier 1 RvR)
Havoc (Tier 2 PvE)
Devastator (Tier 3 RvR)
Annihilator (Tier 4 RvR)
Redeye (Tier 4 Dungeon, Gunbad). Conqueror is an honorable mention here, but it's not worth the crests in my honest opinion. If you get the gear from gold bags, then sure go for it, but i personally ran full Redeye at this level.
Vanquisher (Tier 4 RvR). You will sit in Full vanquisher until your best in slot. Invader is an honorable mention, but the pieces are too expensive to be worthwhile.
Best in Slot - Here we go, Best in Slot. I'll go piece by piece and what talisman to throw into them.
Sovereign Gorget of the Souldrinker - +24 Wounds.
Sovereign Painmantle of the Souldrinker - +136 Armor Bonus
Sovereign Paincloak of the Souldrinker - +24 Toughness
Triumphant Breastscale - +136 Armor Bonus
Sovereign Armscales of the Souldrinker - +136 Armor Bonus
Triumphant Bladebelt
Triumphant Bloodwades - +136 Armor Bonus
Apostles Xiphos of Tyranny (RR45 Weapon) - +24 Toughness
Apostles Chalice of Tyranny (RR45 Weapon) - +24 Initiative
Exquisite Gunbad Diamond
Platnium Citrine Annulus
Triumphant Blood Coil Replica (expensive I know, I personally run Sentinel Pain Link and throw a +4% Heal Crit talisman in it from the soulstones because I personally cannot be bothered farming 10,000 crests for it, I'd rather just buy another full set of Sov.)
Sovereign Blood Coil of the Souldrinker
This will be your Best in Slot setup for Chalice DoK. It is expensive, I know but it is very worth it. These will be your stats when you are fully buffed up -



When you hit Rank 36, you will definitely want to run atleast 2 Piece Genesis of the Curative.
I think this pretty much covers everything that you'll need to know. Feel free to ask any questions, I would be happy to help! You can reach me via posting either here in the forum, Contacting me on Discord (Techno2123) Or reaching out to me in game.